Static charge emanet build up on the inside of the plastic chamber. This can attract particles of medicine, and reduce the output when the spacer is used. An acute exacerbation is more commonly known birli a 'flare-up'. An acute exacerbation of chronic obstructive pulmonary disease (COPD) is a sudden worsening https://search.grainger.illinois.edu/searchaidlog3/sourcelognew.asp?ID=782151&goog--https://tr.wikipedia.org/wiki/Vitamin