Environmental or self-antigens and homotypic interactions bring about BCR and Toll-like receptor (TLR) signaling, amplifying the response of CLL cells to other indicators in the microenvironment and rising the activation of anti-apoptotic and proliferation pathways.31,32 Genomic studies have determined recurrent mutations in genes regulating tumor cell-microenvironment interactions, t... https://marlborougha864rai1.wikifiltraciones.com/user