Federal primer cups are comfortable. I don't know if it would make any variation in handguns, but they aren't suggested for use in a Garand. "Offered satisfactory penetration, a larger diameter bullet should have an edge in wounding performance. It will harm a blood vessel the smaller projectile scarcely misses. https://federalarprimers41627.vidublog.com/31064857/federal-champion-210-large-rifle-primers-for-dummies