You will find there's release of norepinephrine in the descending inhibitory bulbospinal neurons that binds to alpha-2-receptors during the dorsal horn to lower afferent ache transmission and deliver analgesia. Therefore, medications like clonidine that goal alpha-two receptors can influence the transmission of soreness. Clonidine is dispersed in breast milk; https://getsocialnetwork.com/story5311347/the-2-minute-rule-for-onolidine